Purpose: The quality of the IMAGE in SPECT scans depends on the imaging parameters which are determined experimentally in the field of nuclear medicine. Designing a dedicated scanning parameter for 177Lu-DOTATATE SPECT IMAGEs is required to optimize reconstruction. Therefore, this study aims to evaluate the effect of different filters on IMAGE quality for bone SPECT scanning using 177Lu-DOTATATE. Materials and Methods: The filtered back-projection reconstruction method was used in neuro-endocrine tumor scanning using 177Lu-DOTATATE. Three hours after injection of 177Lu-DOTATATE, SPECT scans from 177Lu-DOTATATE for 30 patients were acquired using a dual-head EvoExel detector system. Seven parameters were considered, including the contrast/noise ratio, injection activity, uptake duration, acquisition time per injection, frame time, measuring time, and type of filters. Results: In all cases, the application of different filters increased Contrast to Noise Ratio (CNR) (9. 1%, 1. 8%, 10. 9%, 61. 8%, 23. 6%, 29. 1%, and 58. 2% for Wiener, Butterworth, Parzen, Metz, Ramp, Shepp-Logan, and Hamming filters, reSPECTively). The percentage of increase in Signal-to-Noise Ratio (SNR) was 3. 3%, 1. 7%,-24%, 21. 7%, 9. 8%, 11. 9%, and 20. 6%. Conclusion: Based on the quantitative analysis of the results, the application of the Metz filter (power 2) and Hamming filter (with 0. 27, 0. 47, and 0. 67 cut-off frequencies) on SPECT scans of neuro-endocrine tumors is recommended because of their capacity to provide high-quality IMAGEs.